Ozone ablation



(1) Oxidative proteoglycans in the nucleus pulposus: O3 is a strong oxidant that can rapidly oxidize proteoglycans in the nucleus pulposus after injection into the intervertebral disc, reducing the osmotic pressure of the nucleus pulposus, causing water loss, degeneration, drying, necrosis, and atrophy, thereby reducing the pressure inside the intervertebral disc and relieving or eliminating the compression on nerve roots.
(2) Anti inflammatory effect: The anti-inflammatory effect of O3 is to directly improve the hypoxia caused by arterial compression and venous stasis by antagonizing the release of immune factors and oxygen ions in the inflammatory response, ultimately reducing nerve root edema and adhesion, thus achieving the goal of relieving pain.
(3) Analgesic effect: The analgesic effect of O3 still directly acts on the surface of the intervertebral disc, adjacent ligaments, facet processes, and widely distributed nerve endings in the lumbar muscles. These nerve endings are activated by inflammatory factors and chemical substances released by the protruding nucleus pulposus (5-hydroxytryptamine, bradykinin, substance P, phosphatidylcholine A2, etc.), causing reflexive lumbar muscle spasms and back pain. O3 inhibits the response of these nerve endings, achieving the purpose of analgesia.
(4) Inhibition of immune response: Glycoproteins and β - proteins released after the rupture of the fibrous ring act as antigenic substances, causing the body to produce an immune response. Ozone has an inhibitory effect on immunity.
 

Indications for intervertebral disc ozone ablation:
1. The clinical symptoms are obvious, including persistent lower back and leg pain, claudication, etc;
2. Positive signs of spinal nerve compression or abnormal skin sensation, such as positive results in straight leg elevation test;
3. Those who have undergone conservative treatment for more than 4 weeks with poor results;
4. Diagnosed with inclusive or simple intervertebral disc herniation or bulging through imaging such as CT or MRI, and the imaging findings are consistent with clinical symptoms and signs.
5. Patients who have undergone surgical treatment or other minimally invasive treatments for intervertebral discs with poor results;
6. Low back pain that has been treated conservatively but has not been cured for a long time, without obvious symptoms of nerve compression, but has been confirmed by imaging to have corresponding intervertebral disc lesions, such as disc herniation, and other causes have been ruled out.


Contraindications for radiofrequency target ablation:
1. Individuals over 65 years old;
2. X-ray examination shows that the height of the intervertebral disc is 50% lower than the normal value;
3. CT or MRI examination results show that bony spinal stenosis, osteophyte or posterior longitudinal ligament are the main pressure causing factors;
4. Intervertebral disc herniation;
5. Cervical spondylotic myelopathy;
6. Individuals with obvious progressive neurological symptoms or cauda equina symptoms.
7. None of the above conditions are suitable for this treatment.
The biggest advantage of radiofrequency targeted ablation compared to open surgery is that it does not involve surgery, does not strip the lumbar muscle ligaments, does not damage the lumbar bone structure, is safe, painless, and has a fast recovery. The short-term efficacy and prospects are encouraging, but each new technique should be viewed and observed with caution, and the indications should be strictly followed.


Advantages of ozone therapy:
Simple and safe operation, no need for intervertebral disc endoscope;
It can oxidize and protrude the nucleus pulposus of intervertebral discs, remove aseptic inflammation of nerve roots, and alleviate immune reactions;
Rapid onset of action, high therapeutic effect, and no need for hospitalization;
No obvious complications, ozone itself has a disinfectant effect, and the chance of infection is extremely low;
Minor trauma, almost equivalent to non-invasive.




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